OC-0632: Oxygen enhanced-MRI is feasible, repeatable and detects radiotherapy-induced NSCLC hypoxia changes
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چکیده
منابع مشابه
Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging.
It is well established that hypoxia is prevalent in human tumors and is associated with resistance to radiotherapy and chemotherapy (1–3); furthermore, hypoxia contributes to immune checkpoint activation (4–7), higher likelihood for development of metastasis, and worse overall prognosis (8). Despite this knowledge, there is no established method for measuring hypoxia in patients, nor are there ...
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Fluorescence than Ferrous Hb In the absence of haemoglobin (Hb) products, no cisparinaric Acid (PnA) fluorescence is lost. However, upon addition of ferrous Hb, there is an increasing amount of fluorescence lost. Substantial fluorescence quenching is seen on the addition of extracellular mHb, with significantly less using an intracellular product. This suggests that the cellular membrane is an ...
متن کاملOxygen-enhanced MRI can accurately identify, quantify and map tumour hypoxia in preclinical models
Aim There is need for non-invasive methods to identify, quantify and map tumour hypoxia. In this study we used an emerging technology – R1 oxygen enhanced MRI (OEMRI) – to distinguish those tumour sub-regions that respond to hyperoxic gas challenge from refractory subregions. We hypothesised that the proportion of refractory tumour tissue (Oxy-R) would be a robust biomarker of tumour hypoxia ac...
متن کاملOxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models.
There is a clinical need for noninvasive biomarkers of tumor hypoxia for prognostic and predictive studies, radiotherapy planning, and therapy monitoring. Oxygen-enhanced MRI (OE-MRI) is an emerging imaging technique for quantifying the spatial distribution and extent of tumor oxygen delivery in vivo. In OE-MRI, the longitudinal relaxation rate of protons (ΔR1) changes in proportion to the conc...
متن کاملOxygen-enhanced MRI of the Lung
Highlights • Molecular oxygen is paramagnetic and lowers the T1 of nearby protons • Altering the concentration of inhaled O2 changes lung T1-weighted signal • Potential tool for assessing lung function with widespread availability • While usually considered a measure of regional lung ventilation, likely also a function of regional perfusion • Emerging methods address inherently low SNR and impr...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2018
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(18)30942-3